Nebraska vs. Illinois Prediction, Odds, Picks For College Football Week 10

The Illinois Fighting Illini kick off against the Nebraska Cornhuskers on Friday in a Week 10 college football matchup on FOX.

Let’s take a look at the odds for Nebraska vs. Illinois at DraftKings Sportsbook as of Nov. 6.

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Moneyline

• Illinois: +164
• Nebraska: -198

Spread

• Illinois +4.5: -108
• Nebraska -4.5: -112

Over/Under

• Over 49.5: -115
• Under 49.5: -105

From FOX Sports Research: 

• Nebraska has lost its last three games after starting 5-0. During this three-game losing streak, the Cornhuskers are averaging 13.7 points per game.
• Collin Dixon leads Illinois with 781 receiving yards, third in the Big Ten.
• Nebraska is giving up 15.6 points per game, fifth-fewest in the Big Ten.

How to Watch Illinois vs. Nebraska 

• Date: Friday, Nov. 6, 2026
• Time: 8:00 p.m. ET
• TV: FOX
• Stream: Watch 3 days free on FOX One, FOXSports.com, FOX Sports App
• Location: Gies Memorial Stadium, Champaign, IL