Munster were first on the scoreboard after 15 minutes when Abrahams squeezed over after scooping up John Ryan’s bouncing pass.
Billy Burns added the extras before Lions fought back with Van Wyk’s brilliant try on 27 minutes, with the centre beating six defenders and going over.
Wolhuter levelled with the conversion and then split the posts from a penalty to send his team in with a three-point advantage at half-time.
It was all change in the second half as Munster ran in two tries while Lions failed to add to their tally.
Daly made an instant impact from the bench as Abrahams used turnover ball to surge down the right before sending him over.
Munster stretched their lead to 17-10 when Kendellen, with support from Ryan, burrowed over although Burns was off target for a second time with his conversion attempt.
Munster: Mike Haley; Shay McCarthy, Tom Farrell, Alex Nankivell, Thaakir Abrahams; Billy Burns, Ethan Coughlan; Dian Bleuler, Diarmuid Barron (capt), John Ryan, Evan O’Connell, Fineen Wycherley, Jack O’Donoghue, Alex Kendellen, Gavin Coombes.
Replacements: Niall Scannell, Kieran Ryan, Stephen Archer, Ruadhán Quinn, John Hodnett, Paddy Patterson, Tony Butler, Shane Daly.
Emirates Lions: Quan Horn; Richard Kriel, Henco van Wyk, Marius Louw (capt), Edwill van der Merwe; Kade Wolhuter, Morne van den Berg; Juan Schoeman, PJ Botha, Asenathi Ntlabakanye, Ruben Schoeman, Ruan Delport, Jarod Cairns, WJ Steenkamp, Francke Horn.
Replacements: Franco Marais, Morgan Naude, Conraad van Vuuren, Reinhard Nothnagel, JC Pretorius, Sanele Nohamba, Tapiwa Mafura, Erich Cronje.
